4-吗啉-3-(三氟甲基)苯胺合成路线 （共 3 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=760.051 Torr; 24 h;
参考文献
Bristol-Myers Squibb Pharma Company
Patent: EP946508 B1, 2009 ;
Location in patent: Page/Page column 95 ;
反应条件
nickel T=140°C; 4 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/51366 A2, 2005 ;
Location in patent: Page/Page column 109 ;
WO 2005/051366 A2
反应条件
1: triethylamine / ethyl acetate / 5 h / 20 °C 2: palladium; hydrogen / methanol / 20 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; WANG, Xiaojun; LIN, Runfeng; CAO, Shengtian; WANG, Zhaohe; LI, Jing
Patent: WO2014/12360 A1, 2014 ;
