2,4-二氯-5-氟-7h-吡咯并[2,3-d]嘧啶合成路线 （共 2 条）
反应条件
acetic acid; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile T=70°C; 18 h;
参考文献
ARIAD PHARMACEUTICALS, INC.; DALGARNO, David, C.; HUANG, Wei-sheng; SHAKESPEARE, William, C.; WANG, Yihan; ZHU, Xiaotian
Patent: WO2012/151561 A1, 2012 ;
Location in patent: Page/Page column 58 ;
WO 2012/151561 A1
反应条件
Selectfluorreg;; acetic acid in acetonitrile T=60°C; 5 h;
参考文献
Seela, Frank; Xu, Kuiying
Helvetica Chimica Acta, 2008 , vol. 91, # 6 p. 1083 - 1105
