7-溴-[1,2,4]噻唑并[1,5-a]吡啶合成路线 （共 3 条）
反应条件
1: With hydrogenchloride in water 15 h; Reflux; 2: With sodium hydrogencarbonate in water
参考文献
Katoh, Issei; Aoki, Toshiaki; Suzuki, Hideyuki; Utsunomiya, Iwao; Kuroda, Norikazu; Iwaki, Tsutomu
Patent: US2011/98471 A1, 2011 ;
Location in patent: Page/Page column 59-60 ;
反应条件
1: chloroform / 3 h / 20 °C 2: hydrogenchloride / water / 15 h / Reflux View Scheme
反应条件
1: With tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine in 1,4-dioxane T=20°C; 0.5 h; Inert atmosphere; 2: 7-bromo[1,2,4]triazolo[1,5-a]pyridine; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With potassium acetate in 1,4-dioxane T=80°C; Inert atmosphere;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan
Patent: WO2010/20363 A1, 2010 ;
Location in patent: Page/Page column 124-125 ;
