反应条件
1: 1.) H2, 2.) 1,1'-carbonyldiimidazole, 3.) aq. HCl / 1.) Pd/C
2: 76 percent / p-TsOH / dimethylformamide / 3 h / 65 °C
3: 91 percent / t-BuOK / tetrahydrofuran / 1.) 30 deg C, 4 h; room temperature, overnight
4: 92 percent / aq. HCl / methanol; toluene
View Scheme
参考文献
Pierce; Pierce, Michael E.; Harris; Harris, Gregory D.; Islam; Islam, Qamrul; Radesca; Radesca, Lilian A.; Storace; Storace, Louis; Waltermire; Waltermire, Robert E.; Wat; Wat, Ed; Jadhav; Jadhav, Prabhakar K.; Emmett; Emmett, George C.
Journal of Organic Chemistry, 1996 , vol. 61, # 2 p. 444 - 450
