甲基3,7-二羟基胆烷-24-酸酯 合成路线 （共 12 条）
反应条件
toluene-4-sulfonic acid 2.5 h; Reflux;
参考文献
Molecules, , vol. 15, # 3 p. 2039 - 2059
反应条件
1: ursodeoxycholic acid imidazole salt With phosphoric acid; water in Sec-butyl alcohol T=70°C; Large scale; 2: methanol With hydrogenchloride 2 h; RefluxLarge scale;
参考文献
WO2014/20024 A1, ;
反应条件
sodium tetrahydroborate in acetic acid 3 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 47, # 15 p. 2966 - 2972
反应条件
1: 64 percent / acetic acid / 12 h / Ambient temperature 2: 52 percent / NaBH4 / acetic acid / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 15 p. 2966 - 2972
反应条件
1: sodium; propan-1-ol 2: H2SO4 View Scheme
参考文献
Proceedings of the Japan Academy, , vol. 30, p. 391
反应条件
tert-butylamine borane in methanol 3 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Synthetic Communications, , vol. 11, # 11 p. 875 - 880
反应条件
1.1: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale 2.1: sodium / Sec-butyl alcohol / 0.5 h / |Reflux; |Large scale 2.2: 30 °C / |Large scale 2.3: |Large scale 3.1: water; phosphoric acid / Sec-butyl alcohol / 70 °C / |Large scale 3.2: 2 h / |Reflux; |Large scale View Scheme
3749-87-9 甲基(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-二乙酰氧基-12-羟基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊二烯并[a]菲-17-基]戊酸酯
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反应条件
反应条件
1.1: acetic acid; sodium hypochlorite / ethyl acetate / 30 - 40 °C / |Large scale 2.1: hydrazine hydrate; potassium hydroxide / 1,2-bis-(2-hydroxyethoxy)-ethane / 4 h / 120 - 210 °C / |Large scale 3.1: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale 4.1: sodium / Sec-butyl alcohol / 0.5 h / |Reflux; |Large scale 4.2: 30 °C / |Large scale 4.3: |Large scale 5.1: water; phosphoric acid / Sec-butyl alcohol / 70 °C / |Large scale 5.2: 2 h / |Reflux; |Large scale View Scheme
反应条件
1.1: hydrogenchloride / 1 h / |Reflux; |Large scale 2.1: 4-(N,N-dimethlyamino)pyridine / toluene / 20 °C / |Large scale 2.2: 19 h / 20 °C / |Large scale 3.1: acetic acid; sodium hypochlorite / ethyl acetate / 30 - 40 °C / |Large scale 4.1: hydrazine hydrate; potassium hydroxide / 1,2-bis-(2-hydroxyethoxy)-ethane / 4 h / 120 - 210 °C / |Large scale 5.1: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale 6.1: sodium / Sec-butyl alcohol / 0.5 h / |Reflux; |Large scale 6.2: 30 °C / |Large scale 6.3: |Large scale 7.1: water; phosphoric acid / Sec-butyl alcohol / 70 °C / |Large scale 7.2: 2 h / |Reflux; |Large scale View Scheme
反应条件
1.1: hydrazine hydrate; potassium hydroxide / 1,2-bis-(2-hydroxyethoxy)-ethane / 4 h / 120 - 210 °C / |Large scale 2.1: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale 3.1: sodium / Sec-butyl alcohol / 0.5 h / |Reflux; |Large scale 3.2: 30 °C / |Large scale 3.3: |Large scale 4.1: water; phosphoric acid / Sec-butyl alcohol / 70 °C / |Large scale 4.2: 2 h / |Reflux; |Large scale View Scheme
