1.1: 4-(N,N-dimethlyamino)pyridine / toluene / 20 °C / |Large scale 1.2: 19 h / 20 °C / |Large scale 2.1: acetic acid; sodium hypochlorite / ethyl acetate / 30 - 40 °C / |Large scale 3.1: hydrazine hydrate; potassium hydroxide / 1,2-bis-(2-hydroxyethoxy)-ethane / 4 h / 120 - 210 °C / |Large scale 4.1: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale 5.1: sodium / Sec-butyl alcohol / 0.5 h / |Reflux; |Large scale 5.2: 30 °C / |Large scale 5.3: |Large scale 6.1: water; phosphoric acid / Sec-butyl alcohol / 70 °C / |Large scale 6.2: 2 h / |Reflux; |Large scale View Scheme

water; sodium hydroxide T=97°C; 2 h; Large scale;