1-环丙基-6-氟-7-(1-哌嗪基)-4(1H)-喹啉酮合成路线 (共 4 条)
反应条件
sodium cyanide in dimethyl sulfoxide T=100°C; 17 h;
参考文献
Marks, Kevin R.; Malik, Muhammad; Mustaev, Arkady; Hiasa, Hiroshi; Drlica, Karl; Kerns, Robert J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4585 - 4588
反应条件
formaldehyd in butan-1-ol 3 h; Heating / reflux;
参考文献
Dar Al Dawa Development, and Investment Co.
Patent: EP1245566 A1, 2002 ;
Location in patent: Page 2-3 ;
反应条件
potassium carbonate in methanol T=70°C; 24 h;
参考文献
Nguyen, Son T.; Ding, Xiaoyuan; Butler, Michelle M.; Tashjian, Tommy F.; Peet, Norton P.; Bowlin, Terry L.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5961 - 5963
反应条件
sulfite buffer pH=7.2; UV-irradiation;
参考文献
Helvetica Chimica Acta, , vol. 84, # 9 p. 2508 - 2519