5-氨基-吡唑-3-甲酸乙酯合成路线 （共 4 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; 18 h;
参考文献
Skinner, Philip J.; Webb, Peter J.; Sage, Carleton R; Dang, Huong T.; Pride, Cameron C.; Chen, Ruoping; Tamura, Susan Y.; Richman, Jeremy G.; Connolly, Daniel T.; Semple, Graeme
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4207 - 4209
反应条件
1: With potassium tert-butylate; 18-crown-6 ether in tetrahydrofuran T=0 - 70°C; 0.666667 h; 2: With hydrogenchloride; N-methoxycarbonyl hydrazine in ethanol; water T=30°C; 20 h; Cooling with ice; 3: With potassium carbonate in ethanol; water T=90°C; 0.5 h;
参考文献
AJINOMOTO CO., INC.
Patent: US2011/294781 A1, 2011 ;
Location in patent: Page/Page column 44 ;
反应条件
1: ethyl 3-cyano-2-oxopropionate sodium salt With hydrogenchloride in ethanol; water T=20°C; 0.25 h; 2: N-methoxycarbonyl hydrazine in methanol; water T=20°C; 3: With potassium carbonate in methanol; water T=60°C; 4 h; Heating / reflux;
参考文献
MERZ PHARMA GMBH and CO. KGAA
Patent: US2008/32998 A1, 2008 ;
Location in patent: Page/Page column 20 ;
US 20080032998 A1
反应条件
hydrogenchloride in ethanol; water T=20°C;
参考文献
MERZ PHARMA GMBH and CO. KGAA
Patent: US2008/32998 A1, 2008 ;
Location in patent: Page/Page column 20-21 ;
US 20080032998 A1
