(2R, 3S)-(-)-对甲氧苯基缩水甘油酸甲酯合成路线 （共 38 条）
反应条件
1: HCl / methanol / 24 h / 20 °C 2: DBU / CH2Cl2 / 0.58 h / 5 - 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 19 p. 3131 - 3138
反应条件
2: 83 percent / 2-chloro-1-methylpyridinium methylsulfate, Et3N / CH2Cl2; 1,2-dichloro-ethane / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 2, # 6 p. 403 - 406
反应条件
1: NaNO2, KBr, aq. H2SO4 / diethyl ether / 2 h / Ambient temperature 2: diethyl ether / 0.17 h / Ambient temperature 3: 74 percent / K2CO3 / methanol; diethyl ether / 0.5 h / 0 - 5 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 9 p. 1521 - 1523
反应条件
in tetrahydrofuran; hexane T=-20 - 0°C; 2.5 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 10 p. 1821 - 1823
反应条件
in cyclohexane; water 1.5 h; Ambient temperatureenzymatic hydrolysis by lipase from Candida cylindracea (CCL), pH 7.4, other enzymes; enzymatic transesterification;
参考文献
Gentile; Giordano; Fuganti; Ghirotto; Servi
Journal of Organic Chemistry, 1992 , vol. 57, # 24 p. 6635 - 6635
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 32, # 1 p. 94 - 95
反应条件
1-n-butyl-3-methylimidazolium hexafluorophosphate T=60°C; 7.5 h; Ionic liquid; optical yield given as percent deregioselective reaction;
参考文献
Jain, Renuka; Yadav, Tripti; Kumar, Manoj; Yadav, Ashok K.
Synthetic Communications, 2011 , vol. 41, # 13 p. 1889 - 1900
反应条件
1: aq. FeCl3 / chlorobenzene / 0.75 h / 115 °C 2: methanesulfonic acid / chlorobenzene / 8 h / Heating 3: aq. K2CO3 / ethyl acetate / 8 h / Heating View Scheme
参考文献
Yamada, Shin-Ichi; Yoshioka, Ryuzo; Shibatani, Takeji
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 12 p. 1922 - 1927
