2-甲氧基-4-吡啶甲酸合成路线 （共 12 条）
反应条件
1.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 20 °C 1.2: 1 h / 0 °C 2.1: thionyl chloride / dichloromethane / 2 h / 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; SCHLEGEL, Kelly-Ann; YANG, Zhi-Qiang
Patent: WO2011/84368 A1, 2011 ;
WO 2011/084368 A1
反应条件
1: With thionyl chloride in methanol T=20°C; 2 h; Reflux; 2: With hydrazine hydrate in tetrahydrofuran 0.5 h; Reflux; Product distribution / selectivity;
参考文献
OSLO UNIVERSITY HOSPITAL HF; HOLSWORTH, Daniel; WAALER, Jo; MACHON, Ondrej; KRAUSS, Stefan; VORONKOV, Andrey Edward; GOLDING, Louise
Patent: WO2012/76898 A1, 2012 ;
Location in patent: Page/Page column 45 ;
WO 2012/076898 A1
