3-(1-(二甲基氨基)乙基)苯基 乙基(甲基)氨基甲酸酯合成路线 （共 8 条）
反应条件
potassium carbonate in acetonitrile T=70 - 80°C;
参考文献
EMCURE PHARMACEUTICALS LIMITED
Patent: WO2006/48720 A1, 2006 ;
Location in patent: Page/Page column 4; 11 ;
反应条件
potassium carbonate in dimethyl sulfoxide T=90 - 110°C; 35 - 40 h;
参考文献
SUN PHARMACEUTICAL INDUSTRIES LIMITED; Patel, Hetalkumar Virendrabhai
Patent: WO2003/101917 A2, 2003 ;
Location in patent: Page 12 ;
反应条件
1: in methanol T=26 - 28°C; 16 - 20 h; 2: With hydrogenchloride in water T=12 - 15°C; 3: With sodium carbonate in water T=15 - 20°C; pH=2 - 11; Product distribution / selectivity;
参考文献
GENERICS [UK] LIMITED
Patent: WO2005/61446 A2, 2005 ;
Location in patent: Page/Page column 19 ;
反应条件
1: NAP 226-90; 1,1'-carbonyldiimidazole in acetonitrile T=0 - 20°C; 1.5 h; 2: methyl-N-ethylamine With acetic acid in acetonitrile T=0 - 20°C; 3 h; 3: With sodium hydroxide in diethyl ether; water pH=> 10; Product distribution / selectivity;
参考文献
EMCURE PHARMACEUTICALS LIMITED
Patent: WO2006/48720 A1, 2006 ;
Location in patent: Page/Page column 4; 12 ;
反应条件
in dichloromethane T=-78 - 20°C; 1.5 - 40 h; Product distribution / selectivity;
参考文献
SYNTHON B.V.
Patent: WO2008/37433 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
1: NAP 226-90; 1,1'-carbonyldiimidazole in acetonitrile T=0 - 20°C; 2 h; 2: N-methyl-ethylamine hydrochloride With acetic acid; triethylamine in acetonitrile T=0 - 20°C; 3: With sodium hydroxide in diethyl ether; water pH=> 10; Product distribution / selectivity;
参考文献
Wang, Zhi-Xian; Horne, Stephen E.; Murthy, K.S. Keshava
Patent: US2007/207990 A1, 2007 ;
Location in patent: Page/Page column 3 ;
反应条件
1: NAP 226-90; chloroformic acid 4-nitrophenyl ester With triethylamine in dichloromethane T=0°C; 1 h; 2: methyl-N-ethylamine in dichloromethane T=20°C; 3: With sodium hydroxide in dichloromethane; water pH=> 10; Product distribution / selectivity;
参考文献
Wang, Zhi-Xian; Horne, Stephen E.; Murthy, K.S. Keshava
Patent: US2007/207990 A1, 2007 ;
Location in patent: Page/Page column 3 ;
反应条件
1: 1-chloroethyl chlorocarbonate; NAP 226-90 With triethylamine in dichloromethane T=0°C; 1 h; 2: methyl-N-ethylamine in dichloromethane T=20°C; 3: With sodium hydroxide in dichloromethane; water pH=> 10; Product distribution / selectivity;
参考文献
Wang, Zhi-Xian; Horne, Stephen E.; Murthy, K.S. Keshava
Patent: US2007/207990 A1, 2007 ;
Location in patent: Page/Page column 3 ;
