2-氯-9-(1-甲基乙基)-N-[4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)苯基]-9H-嘌呤-6-胺合成路线 (共 2 条)
反应条件
triethylamine in butan-1-ol T=100°C; 2 h;
参考文献
Oumata, Nassima; Bettayeb, Karima; Ferandin, Yoan; Demange, Luc; Lopez-Giral, Angela; Goddard, Marie-Lorene; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Flajolet, Marc; Greengard, Paul; Meijer, Laurent; Galons, Herve
Journal of Medicinal Chemistry, 2008 , vol. 51, # 17 p. 5229 - 5242
反应条件
1: potassium carbonate / dimethyl sulfoxide / 120 h / 15 - 18 °C 2: triethylamine / butan-1-ol / 24 h / 100 °C View Scheme
参考文献
Demange, Luc; Lozach, Olivier; Ferandin, Yoan; Hoang, Nha Thu; Meijer, Laurent; Galons, Herve
Medicinal Chemistry Research, 2013 , vol. 22, # 7 p. 3247 - 3258