乙基甲基(4S)-4-(2,3-二氯苯基)-2,6-二甲基-1,4-二氢-3,5-吡啶二羧酸酯合成路线 （共 12 条）
反应条件
1: C26H27Cl2NO7S With potassium hydroxide in methanol T=20°C; 1 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 1 h; Inert atmosphere;
参考文献
Kwon, Kuktae; Shin, Jung A.; Lee, Hee-Yoon
Tetrahedron, 2011 , vol. 67, # 52 p. 10222 - 10228
反应条件
in methanol 5.5 h; Reflux; chemoselective reaction;
参考文献
Kwon, Kuktae; Shin, Jung A.; Lee, Hee-Yoon
Tetrahedron, 2011 , vol. 67, # 52 p. 10222 - 10228
反应条件
in methanol chemoselective reaction;
参考文献
Kwon, Kuktae; Shin, Jung A.; Lee, Hee-Yoon
Tetrahedron, 2011 , vol. 67, # 52 p. 10222 - 10228
反应条件
1: KOH / methanol / 2 h / Ambient temperature 2: 1.) KOH / 1.) MeOH; 2.) DMF View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 46 p. 6423 - 6426
反应条件
1.1: pyridine / 4 h / Reflux 2.1: Oxonereg; / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere 3.1: potassium hydroxide / methanol / 1 h / 20 °C / Inert atmosphere 3.2: 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 67, # 52 p. 10222 - 10228
反应条件
1.1: Oxonereg; / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere 2.1: potassium hydroxide / methanol / 1 h / 20 °C / Inert atmosphere 2.2: 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 67, # 52 p. 10222 - 10228
反应条件
potassium hydroxide 1.) MeOH; 2.) DMF; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 30, # 46 p. 6423 - 6426
反应条件
1: 2.) OH(1-) 2: thionyl chloride View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 9 p. 1968 - 1970
反应条件
1: thionyl chloride View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 9 p. 1968 - 1970
反应条件
α1-acid glycoprotein HPLC column resolution of racemate;
参考文献
Helvetica Chimica Acta, , vol. 83, # 4 p. 767 - 776
