2-(4-硝基苯基)丙二酸二乙酯合成路线 （共 10 条）
反应条件
sodium t-butanolate; Pd(NH3)4-NaY in tetrahydrofuran T=110°C; Arylation; 20 h;
参考文献
Djakovitch, Laurent; Koehler, Klaus
Journal of Organometallic Chemistry, 2000 , vol. 606, # 2 p. 101 - 107
反应条件
1: (4-nitro-phenyl)-acetic acid ethyl ester With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1 h; 2: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran T=-78 - 20°C;
参考文献
Katz, Christopher E.; Aube, Jeffrey
Journal of the American Chemical Society, 2003 , vol. 125, # 46 p. 13948 - 13949
反应条件
caesium carbonate; copper(II) oxide in dimethyl sulfoxide T=80°C; P=760.051 Torr; 6 h; Inert atmosphere;
参考文献
Kidwai, Mazaahir; Bhardwaj, Saurav; Poddar, Roona
Beilstein Journal of Organic Chemistry, 2010 , vol. 6, art. no. 35
反应条件
sodium hydride in tetrahydrofuran
参考文献
Gololobov, Yuri G.; Borisov, Yuri A.; Slepchenkov, Nikolii; Barabanov, Sergey; Petrovskii, Pavel V.; Nelyubina, Julija V.
Heteroatom Chemistry, 2010 , vol. 21, # 3 p. 119 - 125
反应条件
1.1: (COCl)2; DMF / tetrahydrofuran / 0.17 h 2.1: LDA / tetrahydrofuran / 1 h / -78 °C 2.2: 78 percent / tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
Katz, Christopher E.; Aube, Jeffrey
Journal of the American Chemical Society, 2003 , vol. 125, # 46 p. 13948 - 13949
反应条件
1.1: LDA / tetrahydrofuran / 1 h / -78 °C 1.2: 78 percent / tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
Katz, Christopher E.; Aube, Jeffrey
Journal of the American Chemical Society, 2003 , vol. 125, # 46 p. 13948 - 13949
反应条件
in dimethyl sulfoxide
参考文献
Beiersdorf-Lilly GmbH
Patent: US5571813 A1, 1996 ;
US 5571813 A
反应条件
1: diphenyl ether / 260 °C 2: H2 / 5percent Pt/sulfide carbon / dimethylformamide View Scheme
参考文献
McQuaid; Smith; Lodge; Pralong; Wikel; Calligaro; O'Malley
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3423 - 3425
反应条件
1: diethyl 2-(4-Nitrophenyl)malonate With sodium hydride in tetrahydrofuran
0.5 h;
2: phenyl isocyanate in tetrahydrofuran
5 h; Further stages.;
参考文献
Linchenko; Krasnova; Petrovskii; Garbuzova; Khrustalev; Gololobov
Russian Chemical Bulletin, 2007 , vol. 56, # 8 p. 1671 - 1674
反应条件
diisobutylaluminium hydride in diethyl ether
T=-78 - 20°C;
参考文献
Katz, Christopher E.; Aube, Jeffrey
Journal of the American Chemical Society, 2003 , vol. 125, # 46 p. 13948 - 13949
