2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶合成路线 （共 35 条）
反应条件
sodium amide in xylene T=130°C; 1.5 h;
参考文献
Choshi, Tominari; Tonari, Akiko; Yoshioka, Haruyuki; Harada, Kenichi; Sugino, Eiichi; Hibino, Satoshi
Journal of Organic Chemistry, 1993 , vol. 58, # 27 p. 7952 - 7954
反应条件
sodium hydroxide; nickel in 1,4-dioxane; ethanol Heating;
参考文献
Bjoerk, Malin; Grivas, Spiros
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 1 p. 101 - 109
反应条件
1: 98 percent / bis(trimethylsilyl)acetamide / 2 h / 140 °C 2: 35 percent / aq. NaOH / Raney nickel / dioxane; ethanol / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 1 p. 101 - 109
反应条件
1: 94 percent / ammonium sulfide / methanol / 0.25 h / 20 °C 2: 98 percent / bis(trimethylsilyl)acetamide / 2 h / 140 °C 3: 35 percent / aq. NaOH / Raney nickel / dioxane; ethanol / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 1 p. 101 - 109
反应条件
1: 97 percent / sodium azide / dimethylsulfoxide / 2 h / 20 °C 2: 94 percent / ammonium sulfide / methanol / 0.25 h / 20 °C 3: 98 percent / bis(trimethylsilyl)acetamide / 2 h / 140 °C 4: 35 percent / aq. NaOH / Raney nickel / dioxane; ethanol / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 1 p. 101 - 109
反应条件
hydrogen fluoride T=100°C; 2.5 h;
参考文献
Chrisman; Knize; Tanga
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 6 p. 1641 - 1649
反应条件
1: 50 percent / dimethylformamide / 2 h / 75 °C 2: 53 percent / H2SO4, HNO3 / 1.5 h / 100 °C 3: 95 percent / (PPh3)4Pd, Na2CO3 / benzene; ethanol / 2 h / Heating 4: 72 percent / ethanol; H2O / 3 h / Heating 5: 1.) H2 / Raney Ni / 1.) RT, 1 atm, 2.) 200 deg C, 3 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 47, # 8 p. 805 - 812
反应条件
1: 53 percent / H2SO4, HNO3 / 1.5 h / 100 °C 2: 95 percent / (PPh3)4Pd, Na2CO3 / benzene; ethanol / 2 h / Heating 3: 72 percent / ethanol; H2O / 3 h / Heating 4: 1.) H2 / Raney Ni / 1.) RT, 1 atm, 2.) 200 deg C, 3 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 47, # 8 p. 805 - 812
反应条件
1: 43 percent / DPPA / ethanol / 26 h / Heating 2: 64 percent / H2SO4, HNO3 / 20 h / 20 °C 3: 82 percent / K2CO3 / acetone / 6 h / Heating 4: 75 percent / aq. KOH / ethanol / 1 h / Heating 5: 61 percent / (PPh3)4Pd, NaCO3 / benzene; ethanol / 2 h / Heating 6: 1.) H2 / Raney Ni / 1.) RT, 1 atm, 2.) 200 deg C, 3 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 47, # 8 p. 805 - 812
反应条件
1: 64 percent / H2SO4, HNO3 / 20 h / 20 °C 2: 82 percent / K2CO3 / acetone / 6 h / Heating 3: 75 percent / aq. KOH / ethanol / 1 h / Heating 4: 61 percent / (PPh3)4Pd, NaCO3 / benzene; ethanol / 2 h / Heating 5: 1.) H2 / Raney Ni / 1.) RT, 1 atm, 2.) 200 deg C, 3 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 47, # 8 p. 805 - 812
