2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶合成路线 （共 35 条）
反应条件
1: 95 percent / (PPh3)4Pd, Na2CO3 / benzene; ethanol / 2 h / Heating 2: 72 percent / ethanol; H2O / 3 h / Heating 3: 1.) H2 / Raney Ni / 1.) RT, 1 atm, 2.) 200 deg C, 3 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 47, # 8 p. 805 - 812
反应条件
1: 72 percent / ethanol; H2O / 3 h / Heating 2: 1.) H2 / Raney Ni / 1.) RT, 1 atm, 2.) 200 deg C, 3 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 47, # 8 p. 805 - 812
反应条件
1: 82 percent / K2CO3 / acetone / 6 h / Heating 2: 75 percent / aq. KOH / ethanol / 1 h / Heating 3: 61 percent / (PPh3)4Pd, NaCO3 / benzene; ethanol / 2 h / Heating 4: 1.) H2 / Raney Ni / 1.) RT, 1 atm, 2.) 200 deg C, 3 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 47, # 8 p. 805 - 812
反应条件
1: 75 percent / aq. KOH / ethanol / 1 h / Heating 2: 61 percent / (PPh3)4Pd, NaCO3 / benzene; ethanol / 2 h / Heating 3: 1.) H2 / Raney Ni / 1.) RT, 1 atm, 2.) 200 deg C, 3 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 47, # 8 p. 805 - 812
反应条件
1: 61 percent / (PPh3)4Pd, NaCO3 / benzene; ethanol / 2 h / Heating 2: 1.) H2 / Raney Ni / 1.) RT, 1 atm, 2.) 200 deg C, 3 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 47, # 8 p. 805 - 812
反应条件
1: 100 percent / n-BuLi / tetrahydrofuran; hexane / 1.) r.t., 30 min, 2.) r.t., 12 h 2: 93.5 percent / n-BuLi / diethyl ether; hexane / 1.) -78 deg C, 1 h, 2.) r.t., 12 h 3: 98 percent / diphenyl phosphorazidate, Et3N / benzene / 1 h / 50 °C 4: 86.4 percent / 1,2-dichloro-benzene / 0.25 h / 190 °C 5: 41.5 percent / NaAlH2(OCH2CH2OCH3)2 / toluene / 20 h / Heating 6: 90.2 percent / NaNH2 / xylene / 1.5 h / 130 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 27 p. 7952 - 7954
反应条件
1: 93.5 percent / n-BuLi / diethyl ether; hexane / 1.) -78 deg C, 1 h, 2.) r.t., 12 h 2: 98 percent / diphenyl phosphorazidate, Et3N / benzene / 1 h / 50 °C 3: 86.4 percent / 1,2-dichloro-benzene / 0.25 h / 190 °C 4: 41.5 percent / NaAlH2(OCH2CH2OCH3)2 / toluene / 20 h / Heating 5: 90.2 percent / NaNH2 / xylene / 1.5 h / 130 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 27 p. 7952 - 7954
反应条件
1: 98 percent / diphenyl phosphorazidate, Et3N / benzene / 1 h / 50 °C 2: 86.4 percent / 1,2-dichloro-benzene / 0.25 h / 190 °C 3: 41.5 percent / NaAlH2(OCH2CH2OCH3)2 / toluene / 20 h / Heating 4: 90.2 percent / NaNH2 / xylene / 1.5 h / 130 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 27 p. 7952 - 7954
反应条件
1: 86.4 percent / 1,2-dichloro-benzene / 0.25 h / 190 °C 2: 41.5 percent / NaAlH2(OCH2CH2OCH3)2 / toluene / 20 h / Heating 3: 90.2 percent / NaNH2 / xylene / 1.5 h / 130 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 27 p. 7952 - 7954
反应条件
1: 41.5 percent / NaAlH2(OCH2CH2OCH3)2 / toluene / 20 h / Heating 2: 90.2 percent / NaNH2 / xylene / 1.5 h / 130 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 27 p. 7952 - 7954
