4-氨基-3-溴-5-硝基苯甲酸甲酯合成路线 （共 8 条）
反应条件
bromine in dichloromethane Heating;
参考文献
Charrier, Nicolas; Demont, Emmanuel; Dunsdon, Rachel; Maile, Graham; Naylor, Alan; O'Brien, Alistair; Redshaw, Sally; Theobald, Pam; Vesey, David; Walter, Daryl
Synlett, 2005 , # 20 art. no. D23305ST, p. 3071 - 3074
反应条件
in methanol; dichloromethane T=0 - 25°C;
参考文献
WO2010/111058 A1, ;
Page/Page column 88 ;
WO 2010/111058 A1
反应条件
1: SOCl2 / 16 h / Heating 2: Br2 / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Synthesis, , # 20 p. 3467 - 3477
反应条件
methanol; tin(ll) chloride T=60°C; 4 h;
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
Location in patent: Page/Page column 39; 40 ;
反应条件
1: pyridine / CH2Cl2 / 1 h / 0 °C
2: K2CO3 / acetonitrile / 3 h / Heating
3: 83 percent / K2CO3 / methanol / 0.75 h / 20 °C
View Scheme
参考文献
Charrier, Nicolas; Demont, Emmanuel; Dunsdon, Rachel; Maile, Graham; Naylor, Alan; O'Brien, Alistair; Redshaw, Sally; Theobald, Pam; Vesey, David; Walter, Daryl
Synlett, 2005 , # 20 art. no. D23305ST, p. 3071 - 3074
反应条件
1: pyridine / CH2Cl2 / 1 h / 0 °C
2: K2CO3 / acetonitrile / 3 h / Heating
3: 83 percent / K2CO3 / methanol / 0.75 h / 20 °C
4: Fe; glacial AcOH
View Scheme
参考文献
Charrier, Nicolas; Demont, Emmanuel; Dunsdon, Rachel; Maile, Graham; Naylor, Alan; O'Brien, Alistair; Redshaw, Sally; Theobald, Pam; Vesey, David; Walter, Daryl
Synlett, 2005 , # 20 art. no. D23305ST, p. 3071 - 3074
反应条件
1: With pyridine in dichloromethane
T=0°C; 1 h;
2: With methanol in dichloromethane
0.25 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/94430 A1, 2004 ;
Location in patent: Page 16 ;
WO 2004/094430 A1
反应条件
1: pyridine / CH2Cl2 / 1 h / 0 °C
2: K2CO3 / acetonitrile / 3 h / Heating
3: TBACl; Na2CO3; HCO2Na / Pd(OAc)2 / dimethylformamide / 1 h / 100 °C
View Scheme
参考文献
Charrier, Nicolas; Demont, Emmanuel; Dunsdon, Rachel; Maile, Graham; Naylor, Alan; O'Brien, Alistair; Redshaw, Sally; Theobald, Pam; Vesey, David; Walter, Daryl
Synlett, 2005 , # 20 art. no. D23305ST, p. 3071 - 3074
