4-甲基-1,2,4-三唑合成路线 （共 8 条）
反应条件
in acetonitrile T=80°C; 3 h;
参考文献
Begtrup, Mikael; Larsen, Peter
Acta Chemica Scandinavica, 1990 , vol. 44, # 10 p. 1050 - 1057
反应条件
potassium carbonate in acetonitrile T=45°C; 48 h;
参考文献
Ueng, Shau-Hua; Fensterbank, Louis; Lacote, Emmanuel; Malacria, Max; Curran, Dennis P.
Organic Letters, 2010 , vol. 12, # 13 p. 3002 - 3005
反应条件
sodium hydride 1.) acetonitrile, 0 deg C, 24 h, 2.) dichloromethane, a) from -25 to 20 deg C, 1 h, b) 20 deg C, 72 h; Yield given. Multistep reaction;
参考文献
Begtrup, Mikael; Larsen, Peter
Acta Chemica Scandinavica, 1990 , vol. 44, # 10 p. 1050 - 1057
反应条件
in 1,4-dioxane T=100°C; Cycloaddition; 3 h;
参考文献
Morita, Hiroyuki; Takeda, Masahiro; Yoshimura, Toshiaki; Fujii, Takayoshi; Ono, Shin; Shimasaki, Choichiro
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6730 - 6737
反应条件
in dichloromethane T=20°C; 48 h; Further byproducts given;
参考文献
Kurenkov, A. A.; Pevzner, M. S.
Russian Journal of Organic Chemistry, 1995 , vol. 31, # 8 p. 1118 - 1121
Zhurnal Organicheskoi Khimii, 1995 , vol. 31, # 8 p. 1227 - 1230
反应条件
1: orthoformic acid triethyl ester; hydrazinecarboxaldehyde in methanol Heating; 2: methylamine in methanol Heating; Further stages.;
参考文献
Roubeau; Alcazar Gomez; Balskus; Kolnaar; Haasnoot; Reedijk
New Journal of Chemistry, 2001 , vol. 25, # 1 p. 144 - 150
反应条件
potassium carbonate Reflux;
参考文献
Guo, Shuai; Huynh, Han Vinh
Organometallics, 2012 , vol. 31, # 12 p. 4565 - 4573
反应条件
N-bromosuccinmide in chloroform T=20 - 50°C;
参考文献
Gibson, Christoph; Schnatbaum, Karsten; Pfeifer, Jochen R.; Locardi, Elsa; Paschke, Matthias; Reimer, Ulf; Richter, Uwe; Scharn, Dirk; Faussner, Alexander; Tradler, Thomas
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4370 - 4379
