2-氟-5-甲氧基苯甲醛合成路线 （共 19 条）
反应条件
sodium carbonate; dimethyl sulfoxide T=45 - 50°C; 21 h;
参考文献
Journal of the American Chemical Society, , vol. 109, # 2 p. 341 - 348
反应条件
potassium fluoride in N,N-dimethyl-formamide T=25°C; 1 h;
参考文献
Tetrahedron Letters, , vol. 28, # 36 p. 4139 - 4142
反应条件
1: 90 percent / N-bromosuccinimide; PhCO3H / CCl4 / Heating 2: 82 percent / aq. NaHCO3 / 32 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 3 p. 677 - 694
反应条件
1: 1) NaNO2, 3M HCl, 2) NH4PF6 / 1) 0 to 5 deg C, 3) heating with Bunsen burner to white fumes 2: 71 percent / NBS / CCl4 / 4 h / Heating 3: 68 percent / DMSO, Na2CO3 / 21 h / 45 - 50 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 109, # 2 p. 341 - 348
反应条件
sodium hydrogencarbonate 32 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 3 p. 677 - 694
反应条件
sec.-butyllithium 1.) THF, -40 deg C, 15 min, 2.) THF, from -40 deg C to RT; Multistep reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 28, # 2 p. 103 - 115
反应条件
sec.-butyllithium 1.) THF, from -78 to -70 deg C, 15 min, 2.) THF; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 53, # 14 p. 3145 - 3147
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine 1.) hexane, THF, -78 deg C, 2.) -78 deg C; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 33, # 49 p. 7499 - 7502
参考文献
American Cyanamid Co.
Patent: US5519133 A1, 1996 ;
反应条件
chlorine in acetic acid 4 h;
参考文献
Gust, R; Schoenenberger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 103 - 115
