2-氟-5-甲氧基苯甲醛合成路线 （共 19 条）
反应条件
1: potassium carbonate / 1,2-dimethoxy-ethane / 40 °C 2: hydrazine / 1,2-dimethoxy-ethane / Heating View Scheme
参考文献
Lukin, Kirill; Hsu, Margaret C.; Fernando, Dilinie; Leanna, M. Robert
Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8166 - 8172
反应条件
sodium hydride 1.) DMSO, 20 deg C, 2.) DMSO, 2-5 min; Yield given. Multistep reaction;
参考文献
MethylGene Inc.
Patent: US2010/279983 A1, 2010 ;
Location in patent: Page/Page column 22 ;
US 20100279983 A1
参考文献
American Cyanamid Co.
Patent: US5519133 A1, 1996 ;
反应条件
1: 38 percent / BBr3 / CH2Cl2 / -70 °C 2: 83 percent / K2CO3 / dimethylformamide / 3 h / 110 °C View Scheme
参考文献
Langer, Oliver; Dolle, Frederic; Valette, Heric; Halldin, Christer; Vaufrey, Francoise; Fuseau, Chantal; Coulon, Christine; Ottaviani, Michele; Nagren, Kjell; Bottlaender, Michel; Maziere, Bernard; Crouzel, Christian
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 677 - 694
反应条件
boron tribromide in dichloromethane T=-70°C;
参考文献
Langer, Oliver; Dolle, Frederic; Valette, Heric; Halldin, Christer; Vaufrey, Francoise; Fuseau, Chantal; Coulon, Christine; Ottaviani, Michele; Nagren, Kjell; Bottlaender, Michel; Maziere, Bernard; Crouzel, Christian
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 677 - 694
反应条件
In(OiPr)3; isopropyl alcohol T=25°C; Meerwein-Ponndorf-Verley reduction; 0.08 h; Inert atmosphere;
参考文献
Lee, Jaeyoung; Ryu, Taekyu; Park, Sangjune; Lee, Phil Ho
Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4821 - 4825
反应条件
1: K2CO3 / N,N-dimethyl-acetamide / 2 h / 170 °C
2: MgSO4 / toluene / 100 °C
3: cesium pivalate / Pd(OAc)2; 1,1-bis(diphenylphosphino)methane / dimethylformamide / 24 h / 100 °C
4: aq. HCl / acetone
View Scheme
参考文献
Zhao, Jian; Yue, Dawei; Campo, Marino A.; Larock, Richard C.
Journal of the American Chemical Society, 2007 , vol. 129, # 16 p. 5288 - 5295
反应条件
1.1: potassium hydroxide / methanol; N,N-dimethyl-formamide / 2 h / -10 °C / |Inert atmosphere
1.2: 0.5 h / -10 °C / pH 1 / |Inert atmosphere
2.1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / |Inert atmosphere
View Scheme
参考文献
Resch, Verena; Lechner, Horst; Schrittwieser, Joerg H.; Wallner, Silvia; Gruber, Karl; MacHeroux, Peter; Kroutil, Wolfgang
Chemistry - A European Journal, 2012 , vol. 18, # 41 p. 13173 - 13179
反应条件
1: 78 percent / NaBH4 / methanol / 0.5 h / Ambient temperature
2: 80 percent / pyridine, SOBr2 / CH2Cl2 / 3 h / Heating
View Scheme
参考文献
Monclus, Michel; Masson, Carine; Luxen, Andre
Journal of Fluorine Chemistry, 1995 , vol. 70, # 1 p. 39 - 44
