2,4-二氯-6-甲氧基喹唑啉合成路线 （共 7 条）
反应条件
trichlorophosphate; N,N-dimethyl-aniline 5 h; Reflux;
参考文献
US2010/68197 A1, ;
Page/Page column 17 ;
反应条件
1: bis(trichloromethyl) carbonate With triethylamine; triphenyl-phosphine oxide in chlorobenzene T=20°C; 0.5 h; Cooling with ice; 2: 2-amino-5-methoxybenzonitrile in chlorobenzene T=120°C; 6 h;
参考文献
Heterocycles, , vol. 85, # 6 p. 1417 - 1426
反应条件
in ice-water; toluene; trichlorophosphate
反应条件
1: 1.5 h / 200 °C 2: 1.8 g / POCl3; N,N-dimethylaniline / 16 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2297 - 2300
反应条件
sodium hydroxide in water T=30°C; 3 h;
参考文献
Ram, Vishnu Ji; Farhanullah; Tripathi, Brajendra K.; Srivastava, Arvind K.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 11 p. 2439 - 2444
反应条件
1: With ammonia; water; zinc in dichloromethane 2 h; Reflux; 2: With hydrogenchloride in dichloromethane; water pH=7;
参考文献
N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian; STOUT, Adam
Patent: WO2012/83165 A1, 2012 ;
Location in patent: Page/Page column 96 ;
参考文献
Taisho Pharmaceutical Co. Ltd.; Nissan Chemical Industries, Ltd.
Patent: EP2003131 A1, 2008 ;
Location in patent: Page/Page column 60-61 ;
EP 2003131 A1
