3-(2,6-二氯-苯基)-丙醛合成路线 (共 3 条)
反应条件
triethylamine in dichloromethane; dimethyl sulfoxide T=0 - 20°C; 3.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/76260 A2, 2007 ;
Location in patent: Page/Page column 53 ;
反应条件
1: N-ethylidenecyclohexylamine With lithium diisopropyl amide 2: (2,6-dichlorophenyl)-methyl chloride in tetrahydrofuran T=15 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; water T=0°C;
参考文献
Tosoh Corporation
Patent: US6346621 B1, 2002 ;
Location in patent: Page column 16 ;
反应条件
(i) aq. EtOH, (ii) H2, PtO2, aq. AcOH; Multistep reaction;
参考文献
Bream,J.B. et al.
Journal of Medicinal Chemistry, 1970 , vol. 13, # 6 p. 1051 - 1057