(+)-4-(2-甲氧基乙基)苯基缩水甘油醚合成路线 (共 13 条)
反应条件
potassium carbonate in butanone 18 h; Heating / reflux;
参考文献
ARTESIAN THERAPEUTICS, INC.
Patent: WO2006/60122 A2, 2006 ;
Location in patent: Page/Page column 80 ;
WO 2006/060122 A2
反应条件
in N,N-dimethyl-formamide; mineral oil
反应条件
potassium carbonate in acetonitrile 14 h; Reflux; optical yield given as percent ee;
参考文献
Pujala, Brahmam; Rana, Shivani; Chakraborti, Asit K.
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 8768 - 8780
反应条件
trimethylsilylazide; β-cyclodextrin in ethanol; water T=37°C; racemat resolution; 5 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 22 p. 4261 - 4264
反应条件
potassium carbonate in acetonitrile 14 h; Reflux; optical yield given as percent ee;
参考文献
Pujala, Brahmam; Rana, Shivani; Chakraborti, Asit K.
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 8768 - 8780
反应条件
Salen-Co(III)OAc in water Ambient temperature;
参考文献
Heterocycles, , vol. 48, # 7 p. 1471 - 1476
反应条件
1: With orthoacetic acid trimethyl ester; pyridinium p-toluenesulfonate in dichloromethane T=20°C; 0.333333 h; 2: With acetyl-bromide in dichloromethane T=20°C; 0.5 h; 3: With potassium carbonate in methanol T=20°C; 1.5 h;
参考文献
Letters in Organic Chemistry, , vol. 9, # 7 p. 516 - 519
反应条件
1.1: K2OsO4*2H2O; potassium carbonate; potassium hexacyanoferrate(III) / tert-butyl alcohol; water / 17.5 h / 0 °C 2.1: pyridinium p-toluenesulfonate; orthoacetic acid trimethyl ester / dichloromethane / 0.33 h / 20 °C 2.2: 0.5 h / 20 °C 2.3: 1.5 h / 20 °C View Scheme
参考文献
Letters in Organic Chemistry, , vol. 9, # 7 p. 516 - 519
反应条件
1.1: potassium carbonate / acetone / |Reflux 2.1: K2OsO4*2H2O; potassium carbonate; potassium hexacyanoferrate(III) / tert-butyl alcohol; water / 17.5 h / 0 °C 3.1: pyridinium p-toluenesulfonate; orthoacetic acid trimethyl ester / dichloromethane / 0.33 h / 20 °C 3.2: 0.5 h / 20 °C 3.3: 1.5 h / 20 °C View Scheme
参考文献
Letters in Organic Chemistry, , vol. 9, # 7 p. 516 - 519
参考文献
Heterocycles, , vol. 48, # 7 p. 1471 - 1476