乙基3-氨基双环[2.2.1]庚烷-2-羧酸酯合成路线 (共 5 条)
反应条件
sodium hydrogencarbonate T=25°C; 0.5 h;
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
Location in patent: Page/Page column 96 ;
参考文献
Anadys Pharmaceuticals, Inc.
Patent: US2012/316156 A1, 2012 ;
反应条件
1.1: ethyl acetate / 0 - 25 °C / Industry scale 1.2: 0 - 25 °C / Industry scale 1.3: 0 - 15 °C / pH 7 / Industry scale 2.1: hydrogenchloride / water / 12 h / 25 °C 3.1: thionyl chloride / 0 °C / Reflux 4.1: sodium hydrogencarbonate / 0.5 h / 25 °C View Scheme
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
反应条件
1: hydrogenchloride / water / 12 h / 25 °C 2: thionyl chloride / 0 °C / Reflux 3: sodium hydrogencarbonate / 0.5 h / 25 °C View Scheme
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
反应条件
ammonia in methanol 336 h;
参考文献
Stajer, Geza; Szabo, Angela E.; Fueloep, Ferenc; Bernath, Gabor; Sohar, Pal
Chemische Berichte, 1987 , vol. 120, p. 259 - 264