sodium methylate in 1,4-dioxane; methanol T=8°C; 17 h; Yields of byproduct given;

1: 1.) hexamethyldisilazane, H2SO4, pyridine, ammonium sulfate, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) reflux, 16 h, 2.) CH3CN, 18 h 2: 427 mg / sodium methoxide / methanol; dioxane / 17 h / 8 °C View Scheme

sodium methylate in 1,4-dioxane; methanol

1: triethylamine / dimethylformamide / Ambient temperature 2: 43 percent / 90percent aq. trifluoroacetic acid / 0.1 h / Ambient temperature View Scheme