(2R)-3-[[(叔丁基)二甲基硅烷基]氧基]-2-甲基丙酸甲酯合成路线 (共 5 条)
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=5°C; Etherification; silylation;
参考文献
Cooksey, John P.; Ford, Rhonan; Kocienski, Philip J.; Pelotier, Beatrice; Pons, Jean-Marc
Tetrahedron, 2010 , vol. 66, # 33 p. 6462 - 6467
反应条件
D-glucose; NAD+ in water T=30°C; 24 h; aq. bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Advanced Synthesis and Catalysis, , vol. 352, # 14-15 p. 2663 - 2666
参考文献
Organic Letters, , vol. 6, # 15 p. 2587 - 2590
反应条件
1: With diisobutylaluminium hydride in hexane; dichloromethane T=-78°C; 0.5 h; 2: With sodium hydroxide; water in hexane; dichloromethane; tert-butyl methyl ether T=20°C;
参考文献
Kong, Ke; Moussa, Ziad; Lee, Changsuk; Romo, Daniel
Journal of the American Chemical Society, 2011 , vol. 133, # 49 p. 19844 - 19856
反应条件
methanol; diisobutylaluminium hydride in toluene T=-42°C; Inert atmosphere;
参考文献
Webb, Damien; Jamison, Timothy F.
Organic Letters, 2012 , vol. 14, # 2 p. 568 - 571