1: 87 percent / pyridine / 1.5 h / Ambient temperature 2: 63 percent / LiI / ethyl acetate / 2.5 h / Heating 3: 94 percent / triethylamine / Pd/C / 1,2-dimethoxy-ethane / 1.25 h / 1810.02 Torr 4: 90 percent / HCl-EtOH / ethyl acetate / 0.5 h / 10 - 15 °C 5: 75 percent / ammonia / methanol / 22 h / Ambient temperature; pH 12 View Scheme

1: 87 percent / pyridine / 1.5 h / Ambient temperature 2: 63 percent / LiI / ethyl acetate / 2.5 h / Heating 3: 94 percent / triethylamine / Pd/C / 1,2-dimethoxy-ethane / 1.25 h / 1810.02 Torr 4: 90 percent / HCl-EtOH / ethyl acetate / 0.5 h / 10 - 15 °C View Scheme

 in  pyridine 1.5 h;  Ambient temperature;   

Multi-step reaction with 3 steps 1: 87 percent / pyridine / 1.5 h / Ambient temperature2: 63 percent / LiI / ethyl acetate / 2.5 h / Heating3: 94 percent / triethylamine / Pd/C / 1,2-dimethoxy-ethane / 1.25 h / 1810.02 Torr