2-溴-N,N-二乙基-4,5-二甲氧基苯甲酰胺合成路线 （共 2 条）
反应条件
1: 77 percent / 2 M aq.Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 18 h / Heating 2: 1) BBr3, 2) glacial HOAc / 1) CH2Cl2, overnight, 2) reflux, 18 h View Scheme
参考文献
Alo, B. I.; Kandil, A.; Patil, P. A.; Sharp, M. J.; Siddiqui, M. A.; et al.
Journal of Organic Chemistry, 1991 , vol. 56, # 12 p. 3763 - 3768
反应条件
1: 1.) t-BuLi / 1.) ether, -78 deg C
2: TsOH / toluene / Heating
3: 1.) LDA / 1.) THF, -78 deg C; 2.) THF, 0 deg C
4: tetrahydrofuran
5: trifluoroacetic acid / Ambient temperature
6: 85 percent / NaBH4 / methanol
View Scheme
参考文献
Iwao, Masatomo; Inoue, Hisao; Kuraishi, Tsukasa
Chemistry Letters, 1984 , p. 1263 - 1266
