1: 51.1 percent / K2CO3 / dimethylformamide / 1.5 h / -40 °C 2: 73 percent / trifluoroacetic acid / CH2Cl2 / 1.5 h / Ambient temperature View Scheme

in water T=20°C; 0.5 h; Inert atmosphere;

<b>Multi-step reaction with 2 steps<br /> </b>1: ethyl acetate / 4 h / -50 &deg;C / Inert atmosphere<br />2: water / 1 h / -50 - 20 &deg;C / Inert atmosphere<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: hydrogenchloride / ethyl acetate / 1.5 h / -50 &deg;C / Inert atmosphere<br />2: ethyl acetate / 4 h / -50 &deg;C / Inert atmosphere<br />3: water / 1 h / -50 - 20 &deg;C / Inert atmosphere<br /> <br /> &nbsp;