5-甲氧基-1,2-二甲基-1H-吲哚-3-羧酸合成路线 (共 3 条)
参考文献
Grinew et al.
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 447,450; engl. Ausg. S. 439, 441
反应条件
1: aqueous NaOH; dioxane 2: ethanolic KOH View Scheme
参考文献
Grinew et al.
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 447,450; engl. Ausg. S. 439, 441
反应条件
1: 5-methoxy-1,2-dimethyl-indole-3-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; 1 - 2 h;
2: methanol T=20 - 60°C; 2 - 16 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/81010 A1, 2004 ;
Location in patent: Page 17 ;
WO 2004/081010 A1