1: With bis-triphenylphosphine-palladium(II) chloride in toluene Inert atmosphereReflux; 2: With potassium fluoride in toluene 0.5 h; 3: With hydrogenchloride; water in toluene T=70°C; 2 h;
参考文献
JANSSEN PHARMACEUTICA NV; MEERPOEL, Lieven; MAES, Louis, Jules, Roger, Marie; DE WIT, Kelly
Patent: WO2011/154298 A1, 2011 ;
Location in patent: Page/Page column 36-37 ;
WO 2011/154298 A1
1: With N,N-dimethyl-formamide dimethyl acetal in N,N-dimethyl-formamide Inert atmosphereReflux; 2: With sodium periodate in tetrahydrofuran; water T=20°C; 1 h;
