1-苄基-1H-咪唑并[4,5-b]吡啶合成路线 （共 7 条）
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate; t-Bu Brett Phos in tert-butyl alcohol
T=110°C; 4 h; Inert atmosphere;
参考文献
Rosenberg, Adam J.; Zhao, Jinbo; Clark, Daniel A.
Organic Letters, 2012 , vol. 14, # 7 p. 1764 - 1767
反应条件
toluene-4-sulfonic acid in N,N-dimethyl acetamide
T=90 - 95°C; 18 h;
参考文献
Khanna; Weier; Lentz; Swenton; Lankin
Journal of Organic Chemistry, 1995 , vol. 60, # 4 p. 960 - 965
反应条件
borane-pyridine complex in dichloromethane; acetic acid
2 h; Ambient temperature;
参考文献
Khanna; Weier; Lentz; Swenton; Lankin
Journal of Organic Chemistry, 1995 , vol. 60, # 4 p. 960 - 965
反应条件
sodium hydride in N,N-dimethyl-formamide
1.) 30 min, 2.) 25 deg C, 3 h;
参考文献
Khanna; Weier; Lentz; Swenton; Lankin
Journal of Organic Chemistry, 1995 , vol. 60, # 4 p. 960 - 965
反应条件
1: trifluoroacetic acid / ethyl acetate / Inert atmosphere
2: NaBH(OAc)3 / ethyl acetate / 0.25 h / Inert atmosphere
3: potassium phosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; t-Bu Brett Phos / tert-butyl alcohol / 4 h / 110 °C / Inert atmosphere
View Scheme
参考文献
Rosenberg, Adam J.; Zhao, Jinbo; Clark, Daniel A.
Organic Letters, 2012 , vol. 14, # 7 p. 1764 - 1767
反应条件
1: NaBH(OAc)3 / ethyl acetate / 0.25 h / Inert atmosphere
2: potassium phosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; t-Bu Brett Phos / tert-butyl alcohol / 4 h / 110 °C / Inert atmosphere
View Scheme
参考文献
Rosenberg, Adam J.; Zhao, Jinbo; Clark, Daniel A.
Organic Letters, 2012 , vol. 14, # 7 p. 1764 - 1767
反应条件
1: trifluoroacetic acid / ethyl acetate / Inert atmosphere
2: NaBH(OAc)3 / ethyl acetate / 0.25 h / Inert atmosphere
3: potassium phosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; t-Bu Brett Phos / tert-butyl alcohol / 4 h / 110 °C / Inert atmosphere
View Scheme
参考文献
Rosenberg, Adam J.; Zhao, Jinbo; Clark, Daniel A.
Organic Letters, 2012 , vol. 14, # 7 p. 1764 - 1767
