in water; acetic acid T=105°C; Hydrolysis;

1: 99 percent / triethylamine / tetrahydrofuran; H2O / 2 h / 25 °C 2: 73 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C 3: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr 4: 94 percent / sodium bicarbonate; potassium iodide / dimethylformamide / 50 - 68 °C 5: 93 percent / H2O; acetic acid / 105 °C View Scheme

1: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr 2: 94 percent / sodium bicarbonate; potassium iodide / dimethylformamide / 50 - 68 °C 3: 93 percent / H2O; acetic acid / 105 °C View Scheme

1: 73 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C 2: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr 3: 94 percent / sodium bicarbonate; potassium iodide / dimethylformamide / 50 - 68 °C 4: 93 percent / H2O; acetic acid / 105 °C View Scheme

1: 94 percent / sodium bicarbonate; potassium iodide / dimethylformamide / 50 - 68 °C 2: 93 percent / H2O; acetic acid / 105 °C View Scheme

1: 2-(4-bromophenyl)-2-methylpropionic acid With sodium hydride in tetrahydrofuran T=25°C; deprotonation; 0.5 h; 2: With tert.-butyl lithium in tetrahydrofuran T=-72°C; Metallation; 0.916667 h; 3: 4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde in tetrahydrofuran T=-72°C; Condensation; 2.5 h;