1-(3-氯-4-硝基苯基)-4-甲基哌嗪合成路线 （共 7 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
CHUA, Peter C.; Haddach, Mustapha; Nagasawa, Johnny Y.; Pierre, Fabrice; Whitten, Jeffrey P.
Patent: US2009/239859 A1, 2009 ;
Location in patent: Page/Page column 353 ;
US 20090239859 A1
反应条件
sodium tert-pentoxide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran T=100°C; 3 h;
参考文献
LABORATORIOS DEL DR. ESTEVE, S.A.
Patent: WO2006/69807 A1, 2006 ;
Location in patent: Page/Page column 104 ;
WO 2006/069807 A1
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran T=100°C; 4 h;
参考文献
Tasler, Stefan; Mies, Jan; Lang, Martin
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 14-15 p. 2286 - 2300
反应条件
1: With sulfuric acid; copper(l) chloride; sodium nitrite Sandmeyer reaction; 2: With hydrogenchloride in water Sandmeyer reaction;
参考文献
Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Breslin, Henry J.; Gingrich, Diane E.; Huang, Zeqi; Lisko, Joseph G.; Mason, Jennifer L.; Milkiewicz, Karen L.; Thieu, Tho V.; Underiner, Ted L.; Wells, Gregory J.; Wells-Knecht, Kevin J.; Dorsey, Bruce D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7325 - 7330
反应条件
1: 60 °C 2: sulfuric acid; copper(l) chloride; sodium nitrite View Scheme
参考文献
Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Breslin, Henry J.; Gingrich, Diane E.; Huang, Zeqi; Lisko, Joseph G.; Mason, Jennifer L.; Milkiewicz, Karen L.; Thieu, Tho V.; Underiner, Ted L.; Wells, Gregory J.; Wells-Knecht, Kevin J.; Dorsey, Bruce D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7325 - 7330
反应条件
1: 60 °C 2: sulfuric acid; copper(l) chloride; sodium nitrite View Scheme
参考文献
Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Breslin, Henry J.; Gingrich, Diane E.; Huang, Zeqi; Lisko, Joseph G.; Mason, Jennifer L.; Milkiewicz, Karen L.; Thieu, Tho V.; Underiner, Ted L.; Wells, Gregory J.; Wells-Knecht, Kevin J.; Dorsey, Bruce D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7325 - 7330
反应条件
1: With iron; acetic acid T=17 - 75°C; 2 h; 2: With diatomaceous earth in methanol; dichloromethane pH=12;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/24824 A1, 2009 ;
Location in patent: Page/Page column 87 ;
WO 2009/024824 A1
