4-溴-3-氧代戊酸甲酯合成路线 （共 12 条）
反应条件
1.1: toluene-4-sulfonic acid / methanol / |Heating
2.1: diisobutylaluminium hydride
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 3 - 20 °C / |Inert atmosphere; |Cooling with ice
4.1: tert-butyl methyl ether / 760.05 Torr / |Heating; |Inert atmosphere
4.2: 36 h / 65 °C / |Heating; |Inert atmosphere
5.1: potassium hydroxide / tetrahydrofuran; water / 3 h
View Scheme
参考文献
Saenz, James; Mitchell, Mark; Bahmanyar, Sami; Stankovic, Nebojsa; Perry, Michael; Craig-Woods, Bridgette; Kline, Billie; Yu, Shu; Albizati, Kim
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 30 - 38
反应条件
1: toluene / Reflux
2: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 20 °C / Cooling with ice
3: triethylamine / dichloromethane / 1 h / 0 - 20 °C
View Scheme
参考文献
Liu, Jingbao; Jiang, Faqin; Jiang, Xizhen; Zhang, Wei; Liu, Jingjing; Liu, Wenlu; Fu, Lei
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 879 - 886
