反应条件
1: PBr3 / diethyl ether / 3 h / 20 °C
2: dimethylformamide / 24 h / Ambient temperature
3: 78 percent / SeO2, t-BuOOH / CH2Cl2 / 25 h / 20 °C
4: 1.) Ti(OiPr)4, CaH2, 4A molecular sieves, D-(-)-DET, 2.) tert-BuOOH / 1.) CH2Cl2, -20 deg C, 15 min, 2.) CH2Cl2, toluene, -40 deg C, 5 h
5: 1.) LDA / 1.) THF, hexane, -78 deg C, 40 min, 2.) THF, hexane, from -78 deg C to RT, 2 h
6: 78 percent / Li, EtNH2 / tetrahydrofuran / 4 h / -78 °C
7: 1.) Ph3P, N-chlorosuccinimide / 1.) THF, 20 deg C, 5 h, 2.) THF, 3 h
8: 98 percent / imidazole / dimethylformamide / 10 h / 50 °C
9: LDA, DABCO / tetrahydrofuran; hexane / 48 h / -78 °C
10: Bu4N+F- / tetrahydrofuran / 24 h / 15 °C
11: 70 percent / Li, EtNH2 / tetrahydrofuran / 3.5 h / -78 °C
View Scheme
参考文献
Lan, Jiong; Li, Jing; Liu, Zuosheng; Li, Yulin; Chan, Albert S. C.
Tetrahedron Asymmetry, 1999 , vol. 10, # 10 p. 1877 - 1885
