反应条件
1: 1) t-butyl hydroperoxide, 2) 10 percent Na2SO3 / 2) CH2Cl2, 3 h 2: 95 percent / p-TsOH / 1 h / Ambient temperature 3: 92 percent / LiAlH4 / diethyl ether / 16 h / Ambient temperature 4: 1) potassium hydride / 1) THF, 0 deg C, 30 min, 2) THF, RT, 16 h 6: tri-n-butylphosphine / CH2Cl2 / 0 deg C, 4 h then RT, 6 h 7: 4 M aq. HCl / CH2Cl2 / 1 h / 0 °C 8: 100 percent / N-(p-toluenesulfonyl)phenyloxaziridine, diisopropylamine / CHCl3 / 1) 0 deg C, 1.5 h, 2) RT, 20 h, 3) reflux, 1 h 9: 67 percent / pyridinium dichromate / dimethylformamide / 36 h / Ambient temperature 10: 1) ozone, 2) NaBH4 / 1) MeOH, CH2Cl2, -78 deg C, 5 min, 2) 20 h, 0 deg C 11: 88 percent / ammonium formate / 10 percent Pd/C / methanol / 2 h / Heating View Scheme
参考文献
Ray, Nicholas C.; Raveendranath; Spencer, Thomas A.
Tetrahedron, 1992 , vol. 48, # 43 p. 9427 - 9432
