反应条件
1.1: n-butyllithium / hexane; diethyl ether / 0.25 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 - 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / toluene / Reflux
3.1: selenium(IV) oxide / 1,4-dioxane / Reflux
3.2: 25 °C
View Scheme
参考文献
DAEWOONG PHARMACEUTICAL CO., LTD.; Kim, In Woo; Kim, Ji Duck; Yoon, Hong Chul; Yoon, Hee Kyoon; Lee, Byung Goo; Lee, Joon Hwan; Lim, Young Mook; Choi, Soo Jin
Patent: US2013/231477 A1, 2013 ;