反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 75 min, 2.) THF, hexane, from -78 deg C to -20 deg C, 2 h
2: 11.2 g / H2, conc. HCl / 20 percent Pd/C / methanol / 16 h
View Scheme
参考文献
Wright, Jon L.; Gregory, Tracy F.; Bigge, Christopher F.; Boxer, Peter A.; Serpa, Kevin; Meltzer, Leonard T.; Wise, Lawrence D.; Cai, Sui Xiong; Hawkinson, Jon E.; Konkoy, Christopher S.; Whittemore, Edward R.; Woodward, Richard M.; Zhou, Zhang-Lin
Journal of Medicinal Chemistry, 1999 , vol. 42, # 13 p. 2469 - 2477
