1: With chloro-trimethyl-silane; magnesium in tetrahydrofuran
T=-5 - 20°C; 0.5 h;
2: With hydrogen bromide in tetrahydrofuran; water
Product distribution / selectivity;
参考文献
Wako Pure Chemical Industries, Ltd.
Patent: EP1676835 A1, 2006 ;
Location in patent: Page/Page column 21-22 ;
1: With chloro-trimethyl-silane; magnesium in tetrahydrofuran
T=-5 - 20°C; 0.5 h;
2: With hydrogen bromide in tetrahydrofuran; water
Product distribution / selectivity;
参考文献
Wako Pure Chemical Industries, Ltd.
Patent: EP1676835 A1, 2006 ;
Location in patent: Page/Page column 21-22 ;
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine in 1,1-dimethylpropan-1-ol
T=80°C; Inert atmosphere; Kinetics;
参考文献
Shekhar, Shashank; Dunn, Travis B.; Kotecki, Brian J.; Montavon, Donna K.; Cullen, Steven C.
Journal of Organic Chemistry, 2011 , vol. 76, # 11 p. 4552 - 4563
