1: 1-chloro-4-bromobenzene With iodine; magnesium in tetrahydrofuran 2 h; Inert atmosphereReflux; 2: tri-n-propyl borate in tetrahydrofuran T=-78 - 20°C; Inert atmosphere; 3: With hydrogenchloride in water
water; magnesium in tetrahydrofuran a 2.0 M soln. of borane (40 mmol) in THF was added to flame dried Mg turnings (12 mmol) at 0°C; slow addn. of the aryl bromide (10 mmol)in THF; stirring at room temp. for 12-16 h; the mixt. was poured into ice-water and acidified with 10percent HCl;; extn. into ether three-times; the combined extracts were dried over NaSO4; removal of solvent under reduced pressure; trituration with petroleum ether; recrystn. from H2O;;
参考文献
Kabalka, George W.; Sastry, Usha; Sastry, K.A.R.; Knapp, Furn F.; Srivastava, Prem C.
Journal of Organometallic Chemistry, 1983 , vol. 259, # 3 p. 269 - 274
1: ortho-nitrobenzoic acid With cupric(II) carbonate in various solvent(s) T=120°C; 0.5 h; 2: 1-chloro-4-bromobenzene With triphenylphosphine; palladium acetylacetonate in various solvent(s) T=120°C; 24 h; Further stages.;
参考文献
Goossen, Lukas J.; Rodriguez, Nuria; Melzer, Bettina; Linder, Christophe; Deng, Guojun; Levy, Laura M.
Journal of the American Chemical Society, 2007 , vol. 129, # 15 p. 4824 - 4833
