1: 4-bromo-phenol With sodium hydride in N,N-dimethyl-formamide; mineral oil T=20°C; 0.333333 h; Inert atmosphere; 2: 2-fluoro-pyridine in N,N-dimethyl-formamide; mineral oil T=105°C; 7 h; 3: With hydrogenchloride in water; N,N-dimethyl-formamide; mineral oil pH=8;
1: pyridine / 3.5 h / 100 °C 2: AlCl3, aluminium chloride / 3.5 h / 150 °C 3: sodium hydride / toluene / 4.5 h / 100 °C / |Cooling with ice View Scheme