反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C 1.2: 2.5 h / 0 °C 2.1: dimethyl zinc; naphthalene-1-sulfonic acid ((R)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl)-amide / n-heptane; toluene / 1.5 h / 20 °C / Inert atmosphere 2.2: 20 h / 20 °C 3.1: ethyl acetate / 1.5 h / 0 - 20 °C 3.2: 18.33 h / 0 - 20 °C 4.1: potassium phosphate / copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine / toluene / 24 h / 120 °C / Inert atmosphere View Scheme
参考文献
LONZA LTD; LONZA GUANGZHOU RESEARCH AND DEVELOPMENT CENTER LTD; DAI, Danmei; LONG, Xiangtian; LUO, Bing; KULESZA, Anna; REICHWAGEN, Jens; GUO, Yanming
Patent: WO2012/97511 A1, 2012 ;
