1: 4-chloro-aniline With BCl3*Me2S in 1,2-dichloro-ethane
T=0°C; Inert atmosphere;
2: chloroacetonitrile With AlCl3, aluminium chloride in 1,2-dichloro-ethane
T=0°C; Friedel-Crafts acylation; Inert atmosphereReflux;
3: With hydrogenchloride; water in 1,2-dichloro-ethane
参考文献
Cinelli, Maris A.; Morrell, Andrew E.; Dexheimer, Thomas S.; Agama, Keli; Agrawal, Surbhi; Pommier, Yves; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5535 - 5552