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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
4-氯苯硫酚
合成路线
(共 616 条)
106-54-7
4-氯苯硫酚
→
反应条件
168910-48-3
5-(4-氯苯基磺酰基)-喹唑啉-2,4-二胺
反应条件
1: 90 percent / K2CO3 / dimethylformamide / 0.5 h / 0 °C 2: 91 percent / SnCl2*2H2O, conc. HCl / bis-(2-methoxy-ethyl) ether / 0.5 h / Ambient temperature 3: 75 percent / 0.5 h / 180 - 190 °C View Scheme
参考文献
Chan; Hong; Kuyper; Baccanari; Joyner; Tansik; Boytos; Rudolph
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3608 - 3616
106-54-7
4-氯苯硫酚
+
75-56-9
环氧丙烷
→
反应条件
32300-53-1
+
13663-04-2
1-(4-氯苯硫基)-2-丙醇
反应条件
BiCl6(3-)*2C4H10N2*ClH*3H(1+)*H2O in neat (no solvent) T=20°C; 0.166667 h; Overall yield = 80 percent;
参考文献
Lu, Hong-Fei; Zhou, Jun-Tao; Cheng, He-Long; Sun, Lei-Lei; Yang, Fei-Fei; Wu, Run-Ze; Gao, Yu-Hua; Luo, Zhi-Bin
Tetrahedron, 2013 , vol. 69, # 52 p. 11174 - 11184
106-54-7
4-氯苯硫酚
+
75-56-9
环氧丙烷
→
反应条件
13663-04-2
1-(4-氯苯硫基)-2-丙醇
反应条件
magnesium oxide; copper T=20°C; 0.5 h; chemoselective reaction;
参考文献
Das, Biswanath; Balasubramanyam, Penagaluri; Krishnaiah, Maddeboina; Veeranjaneyulu, Boyapati; Sudhakar, Dega
Synthetic Communications, 2010 , vol. 40, # 14 p. 2113 - 2121
106-54-7
4-氯苯硫酚
→
反应条件
16191-84-7
2-氯乙基-4-氯苯砜
反应条件
1: sodium hydroxide / methanol 2: thionyl chloride / methanol 3: dihydrogen peroxide; acetic acid View Scheme
参考文献
Padmavathi, Venkatapuram; Venkatesh, Bhumireddy Chinnachennaiahgari; Premakumari, Chokkappagari; Padmaja, Adivireddy
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 646 - 651
106-54-7
4-氯苯硫酚
→
反应条件
175137-71-0
2-({2-[(4-氯苯基)黄酰基]乙基}硫代)乙酸
反应条件
1: sodium hydroxide / methanol 2: thionyl chloride / methanol 3: dihydrogen peroxide; acetic acid 4: sodium hydroxide / methanol View Scheme
参考文献
Padmavathi, Venkatapuram; Venkatesh, Bhumireddy Chinnachennaiahgari; Premakumari, Chokkappagari; Padmaja, Adivireddy
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 646 - 651
106-54-7
4-氯苯硫酚
+
140-88-5
丙烯酸乙酯
→
反应条件
137446-81-2
乙基3-[(4-氯苯基)硫基]丙酸酯
反应条件
triethylamine in chloroform 2 h; Ambient temperature; Yield given;
参考文献
Ishibashi; Mino; Sakata; Inada; Ikeda
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 5 p. 1148 - 1151
107-14-2
氯乙腈
+
106-54-7
4-氯苯硫酚
→
反应条件
18527-19-0
反应条件
sodium methylate in methanol 1) r.t., 2 h, 2) 50 deg C, 5 h;
参考文献
Cervena; Hrubantova; Bartosova; Protiva
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 5 p. 1188 - 1198
106-54-7
4-氯苯硫酚
→
反应条件
19404-18-3
反应条件
1: potassium carbonate / dimethylformamide 2: polyphosphoric acid / toluene / 100 °C View Scheme
参考文献
Mesangeau, Christophe; Fraise, Mikael; Delagrange, Philippe; Caignard, Daniel Henri; Boutin, Jean Albert; Berthelot, Pascal; Yous, Said
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 5 p. 1835 - 1840
78-95-5
+
106-54-7
4-氯苯硫酚
→
反应条件
19404-18-3
反应条件
PPA Yield given. Multistep reaction;
参考文献
Cuberes, M. Rosa; Moreno-Manas, Marcial; Sanchez-Ferrando, Francisco
Magnetic Resonance in Chemistry, 1985 , vol. 23, # 10 p. 814 - 821
4548-45-2
+
106-54-7
4-氯苯硫酚
→
反应条件
25935-62-0
反应条件
lithium hydroxide; ammonium chloride; iron in water; N,N-dimethyl-formamide
参考文献
Eli Lilly and Company
Patent: US4264605 A1, 1981 ;
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