2,6-二甲基-5-庚烯醛合成路线 （共 18 条）
反应条件
1: 73 percent / NaBH4 / methanol / 0.5 h / 25 °C 2: pyridine; diethyl ether / 6 h / Heating 3: 5.84 g / NaBr / dimethylformamide / 5 h / 50 °C 4: 5.8 g / 1.) n-BuLi, TMEDA / 1.) THF, 2.) -15 deg C, 1 h; 20 deg C, 2 h 5: 77 percent / H2SO4 conc. / 4 h / Heating 6: 1.64 g / 1.) n-BuLi / 1.) Et2O, reflux, 1 h, 2.) THF 7: 0.21 g / LiOH / H2O / 8 h / 25 °C / electrochemical reduction 8: diethyl ether / 0.5 h / 0 °C 9: m-CPBA / CH2Cl2 / 12 h / 0 °C View Scheme
参考文献
Lozanova, A. V.; Gul'tyai, V. P.; Karaseva, A. N.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1983 , vol. 32, p. 1241 - 1245
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1983 , # 6 p. 1370 - 1373
反应条件
hydrogen in water T=29.84°C; P=6000.6 Torr; 6 h; AutoclaveSealed tube; chemoselective reaction;
参考文献
Tamura, Masazumi; Tokonami, Kensuke; Nakagawa, Yoshinao; Tomishige, Keiichi
Chemical Communications, 2013 , vol. 49, # 63 p. 7034 - 7036
反应条件
1: sodium tetrahydroborate / ethanol / 0 °C 2: dimethylsulfide; ozone / dichloromethane / -78 °C 3: pyridine; palladium diacetate / toluene / 80 °C / Molecular sieve View Scheme
参考文献
Takeda, Kazutaka; Toyota, Masahiro
Tetrahedron Letters, 2011 , vol. 52, # 44 p. 5872 - 5875
反应条件
oxonium Yield given. Multistep reaction;
参考文献
Isobe, Minoru; Obeyama, Junko; Funabashi, Yasunori; Goto, Toshio
Tetrahedron Letters, 1988 , vol. 29, # 37 p. 4773 - 4776
反应条件
sodium tetrahydroborate; diammonium oxalate in acetonitrile
T=20°C; 0.166667 h;
参考文献
Setamdideh, Davood; Ghahremani, Sahar
South African Journal of Chemistry, 2012 , vol. 65, p. 91 - 97
反应条件
hydrogen in water
T=29.84°C; P=6000.6 Torr; 6 h; AutoclaveSealed tube; chemoselective reaction;
参考文献
Tamura, Masazumi; Tokonami, Kensuke; Nakagawa, Yoshinao; Tomishige, Keiichi
Chemical Communications, 2013 , vol. 49, # 63 p. 7034 - 7036
反应条件
2: copper / 250 °C / 15 Torr
View Scheme
参考文献
Doeuvre
Bulletin de la Societe Chimique de France, 1929 , vol. <4>45, p. 712
反应条件
1: Na2SO4 / CH2Cl2 / 10 h / Heating
2: 81 percent / ethyl chloroformate / diethyl ether / 1 h / Ambient temperature
View Scheme
参考文献
Xiao, Zejun; Timberlake, Jack W.
Tetrahedron, 1998 , vol. 54, # 42 p. 12715 - 12720
