1: CH(CH2CH=CH2)(CO2Me)2 With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; Inert atmosphere; 2: propargyl bromide in tetrahydrofuran; mineral oil Inert atmosphere;
1: 6-methyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one With sodium methylate in methanol Metallation; 2: propargyl bromide in toluene T=20°C; Alkylation; 4 h;
参考文献
Heravi, M. M.; Beheshtiha, Y. Sh.; Oskooie, H. A.; Salarkia, M.; Tajbakhsh, M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1998 , vol. 37, # 7 p. 694 - 696
Eckert, Hellmut; Yesinowski, James P.; Sandman, Daniel J.; Velazquez, Christopher S.
Journal of the American Chemical Society, 1987 , vol. 109, # 3 p. 761 - 768
