反应条件
1: methyl 4-acetylamino-5-chloro-2-hydroxybenzoate With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide
T=12 - 20°C; 1.66 h;
2: propargyl bromide in tetrahydrofuran; N,N-dimethyl-formamide; toluene
T=20°C; 40 h; Heating / reflux;
3: With sodium hydroxide; water in dichloromethane
参考文献
SUVEN LIFE SCIENCES LIMITED; Nirogi, Ramakrishna; Mohammed, Abdul Rasheed; Yarlagadda, Suresh; Ravella, Srinivasa Rao; Shinde, Anil Karbhari; Kamphampati, Ramasastri; Roayapalley, Praveen Kumar; Jayarajan, Pradeep; Bhyrapuneni, Gopinadh; Patnala, Sriramachandra Murthy; Ravula, Jyothsna; Jasti, Venkateswarlu
Patent: US2014/187581 A1, 2014 ;
Location in patent: Page/Page column ;