1: m-C6H4BrBCl2 With i -Pr2Zn in diethyl ether
T=25°C; 2 h;
2: in tetrahydrofuran
T=-30°C; 0.166667 h;
3: propargyl bromide in tetrahydrofuran
T=20°C; Further stages.;
参考文献
Hupe, Eike; Calaza, M. Isabel; Knochel, Paul
Chemical Communications, 2002 , # 13 p. 1390 - 1391
1: 1-(tert-butoxy-carbonyl)piperidine With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran
T=-78°C; 1 h;
2: in tetrahydrofuran
T=-78°C; 0.75 h;
3: propargyl bromide in tetrahydrofuran
T=-78 - 20°C; 3 h; Title compound not separated from byproducts;
参考文献
Dieter, R. Karl; Chen, Ningyi; Yu, Huayun; Nice, Lois E.; Gore, Vinayak K.
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2109 - 2119
