1: diethyl malonate With sodium ethanolate in ethanol
T=50°C; 1 h;
2: propargyl bromide in ethanol
T=50°C; 12 h;
3: formaldehyd With piperidine; hydrogenchloride; potassium hydroxide
more than 3 stages;
参考文献
LES LABORATOIRES SERVER; COMMISSARIAT A 'ENERGIE ATOMIQUE
Patent: US2008/153890 A1, 2008 ;
Location in patent: Page/Page column 7 ;
1: propargyl bromide With aluminium; mercury dichloride in tetrahydrofuran; diethyl ether
2: isobutyraldehyde in tetrahydrofuran; diethyl ether
T=-30°C; Further stages.;
参考文献
Parker, Kathlyn A.; Mindt, Thomas L.
Organic Letters, 2001 , vol. 3, # 24 p. 3875 - 3878
